Stress-Induced Immune Dysregulation: Implications for Wound Healing,...
AbstractThe communication between the central nervous system and the immune system occurs via a complex network of bidirectional signals linking the nervous, endocrine and immune systems. The field of...
View ArticleMinocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation,...
AbstractBackgroundActivation of the peripheral innate immune system stimulates the secretion of CNS cytokines that modulate the behavioral symptoms of sickness. Excessive production of cytokines by...
View ArticleFractalkine receptor (CX 3 CR1) deficiency sensitizes mice to the behavioral...
AbstractBackgroundInteractions between fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) regulate microglial activation in the CNS. Recent findings indicate that age-associated impairments in...
View ArticleCognitive and Behavioral Consequences of Impaired Immunoregulation in Aging
AbstractA hallmark of the aged immune system is impaired immunoregulation of the innate and adaptive immune system in the periphery and also in the central nervous system (CNS). Impaired...
View ArticleRiluzole Partially Rescues Age-Associated, but not LPS-Induced, Loss of...
AbstractImpaired memory may result from synaptic glutamatergic dysregulation related to chronic neuroinflammation. GLT1 is the primary excitatory amino acid transporter responsible for regulating...
View ArticleChronic Inflammation After TBI and Associated Behavioral Sequelae
AbstractTraumatic brain injury (TBI) is associated with peripheral and central inflammatory processes that contribute to injury pathology and functional recovery. Unfortunately, there are no effective...
View ArticleForced turnover of aged microglia induces an intermediate phenotype but does...
AbstractMicroglia are the resident innate immune cells of the central nervous system. Limited turnover throughout the lifespan leaves microglia susceptible to age-associated dysfunction. Indeed, we and...
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